METABOLIK SINDROMDA OYOQ ARTERIYALARINING SEGMENTAR MORFOLOGIK REMODELLANISHI VA RAQAMLI MORFOMETRIK BAHOLASH

Otamurodov A.N

Toshkent davlat tibbiyot universiteti Termiz filiali, Termiz, O‘zbekiston

Khoshimov B.L

Kimyo International University in Tashkent, Toshkent, O‘zbekiston

Keywords: metabolik sindrom, periferik arteriyalar, segmentar remodellanish, raqamli morfometriya, tizza osti arteriyasi, katta boldir arteriyalari, kollagen, elastik tolalar, endoteliy, tomir devori.

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Abstract

Tadqiqotning maqsadi metabolik sindrom sharoitida oyoq arterial o‘zani bo‘ylab morfologik o‘zgarishlarning bir xil kechmasligini aniqlash va distal arterial segmentlarning metabolik ta’sirga sezgirligini morfometrik jihatdan tavsiflashdan iborat. 90 ta jinsiy voyaga yetgan oq erkak laboratoriya kalamushlarida yuqori kaloriyali parhez va 10% li fruktoza eritmasi asosida metabolik sindrom modeli yaratildi. Tashqi yonbosh, son, tizza osti, oldingi va orqa katta boldir arteriyalari tekshirildi. Raqamli morfometriya yordamida tomir diametrlari, devor qalinligi, intima va media ko‘rsatkichlari, ichki elastik membrana, silliq mushak hujayralari, kollagen va elastik tolalar hamda endoteliositlarning morfometrik xususiyatlari baholandi. Tadqiqot metabolik sindromda patologik qayta qurilish arterial o‘zan bo‘ylab notekis tarqalishini ko‘rsatdi. Eng yaqqol o‘zgarishlar tizza osti, oldingi va orqa katta boldir arteriyalarida kuzatildi. Distal segmentlarda tomir bo‘shlig‘ining ko‘proq torayishi, devor qalinlashuvi, elastik tolalar kamayishi, kollagen tolalar ko‘payishi va silliq mushak hujayralari gipertrofiyasi qayd etildi. Natijalar raqamli morfometriya periferik arterial remodellanishning segmentar xususiyatlarini yuqori aniqlikda baholashga imkon berishini ko‘rsatadi.

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