PREEKLAMPSIYANI ERTA ANIQLASH VA OG‘IRLIK DARAJASINI PROGNOZLASHDA ANGIOGEN BIOMARKERLARNING KLINIK AHAMIYATI

Abdusamatova Vazira

Keywords: preeklampsiya, angiogenez, sFlt-1, PlGF, sFlt-1/PlGF, biomarker, platsentar disfunksiya, endotelial disfunksiya, prognoz, homiladorlik.

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Abstract

Preeklampsiya homiladorlik davrida rivojlanadigan, ona va homila uchun jiddiy asoratlar xavfini oshiruvchi ko‘p a’zoli gipertenziv sindromlardan biridir. Kasallik patogenezida platsentar disfunksiya, endotelial shikastlanish va angiogen omillar o‘rtasidagi muvozanatning buzilishi muhim o‘rin tutadi. Mazkur tadqiqotning maqsadi preeklampsiyani erta aniqlash hamda uning og‘ir kechishi va noxush maternal-perinatal oqibatlarini prognozlashda angiogen biomarkerlarning, xususan, eruvchan fms-simon tirozin kinaza-1 (sFlt-1), platsentar o‘sish omili (PlGF) va ularning nisbatining klinik ahamiyatini tahlil qilishdan iborat. Ilmiy adabiyotlar va zamonaviy klinik tadqiqotlar tahlili asosida sFlt-1/PlGF nisbatining diagnostik va prognostik imkoniyatlari baholandi. Natijalar ushbu nisbatning preeklampsiyani qisqa muddatda inkor etish va kasallik og‘irlashishi xavfi yuqori bo‘lgan bemorlarni aniqlashda muhim yordamchi biomarker ekanligini ko‘rsatadi. Shu bilan birga, biomarker natijalari arterial bosim, proteinuriya, trombotsitlar soni, jigar va buyrak faoliyati hamda homila holatini baholash bilan birgalikda talqin qilinishi lozim.

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