TAJRIBAVIY STRESS HOLATIDA ME’DANING MORFOFUNKSIONAL O‘ZGARISHLARI

Adxamjanova Saida Saidvaqqos qizi

Toshkent davlat tibbiyot universiteti, Odam anatomiyasi va OXTA kafedrasi magistri

Mirsharapov U.M.

tibbiyot fanlari doktori, professor (ilmiy rahbar) Toshkent davlat tibbiyot universiteti, Odam anatomiyasi va OXTA kafedrasi, Toshkent, O‘zbekiston

Keywords: stress, me’da, shilliq qavat, morfometriya, organometriya, parietal hujayralar, eroziya, oq kalamush, gistologiya.

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Abstract

Maqsad. Tajribaviy surunkali stress holatida oq laboratoriya kalamushlari me’dasining anatomo-topografik, organometrik va gistologik o‘zgarishlarini dinamikada o‘rganish.

Material va metodlar. Tajriba 120 ta oq laboratoriya kalamushida o‘tkazildi. Hayvonlar ikki guruhga ajratildi: nazorat guruhi (n=70) va labirint qafaslarda surunkali stress modellashtirilgan tajriba guruhi (n=50). Hayvonlar tajribaning 3, 7, 14, 21 va 30-kunlarida efir narkozi ostida eytanaziya qilindi. Organometrik (me’da uzunligi, kengligi, devor qalinligi, massasi), gistologik (gematoksilin-eozin va Van-Gizon bo‘yoqlari) va morfometrik usullar qo‘llanildi.

Natijalar. Stress ta’sirida me’daning nisbiy massasi va devor qalinligi dastlabki 7 kunda ortib, keyinchalik pasaydi. Shilliq qavat qalinligi 14-kunga kelib nazoratga nisbatan sezilarli kamaydi. Eroziyalar soni 7-kunda eng yuqori cho‘qqiga chiqdi. Parietal hujayralar zichligi kamayib, shilliq osti qavatida biriktiruvchi to‘qima tolalari ko‘paydi.

Xulosa. Surunkali stress me’da devorida bosqichma-bosqich rivojlanadigan morfofunksional o‘zgarishlarni keltirib chiqaradi. Bu o‘zgarishlar dastlabki alteratsiya, keyin kompensator-moslashuv va so‘ngra subatrofik bosqichlardan iborat.

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